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the creme has helped my sciatica pain- I rub it on for several days then I actually don't have the pain for several days after! I also Use the cbd oil when I go to bed because it actually helps (sleep apnea) I don't wake up as often as I am accustomed to. I will buy this again! I have given samples to a neighbor she will also be using it! so this stuff really helps but I am thinking it helps more when it is like a nerve pain- that is my thought